Study: How Depressive Thoughts Persevere, Interfere with Memory for People with Depression

Tuesday, November 3, 2015

Intrusive, enduring, depressive thoughts are an ever-present part of daily life for people with depression. A first of its kind study from the Center for BrainHealth at The University of Texas at Dallas published earlier this year in the Journal of Affective Disorders shows that depressive thoughts are maintained for longer periods of time for people with depressed mood, and this extended durationmay reduce the amount of information that these individuals can hold in their memory. The findings have far-reaching implications for understanding how depression damages memory, as well as how depression develops and persists over the course of an individual’s lifetime.

“People with depression or even healthy people with a depressed mood can be affected by depressive thoughts,” explained Center for BrainHealth principal investigator Bart Rypma, Ph.D., who also holds the Meadows Foundation Chair at UT Dallas. “We have known that negative thoughts tend to last longer for those with depression. However, this study is unique in showing that, these thoughts, triggered from stimuli in the environment, can persist to the point that they hinder a depressed person’s ability to keep their train of thought.”

For the study, researchers recruited 75 university undergraduate students; thirty students were classified as having depressive symptoms and 45 participants were categorized as not exhibiting depressive symptoms. All participants were asked to respond to a sentence featuring depressive thoughts, such as “I am sad,” or “People don’t like me,” or neutral information. They were then asked to remember a string of numbers.

Individuals with depressed mood forgot more number strings than people without depressed mood when responding to a sentence with negative information. People with depressed mood who were given the depressive thought first, remembered 31% fewer number strings, compared to people without depressed mood, and people with depressed mood who were given the number string first.

“We all have a fixed amount of information we can hold in memory at one time,” explained the study’s lead author, Nick Hubbard, a doctoral candidate at the Center for BrainHealth working with Dr. Rypma. “The fact that depressive thoughts do not seem to go away once they enter memory certainly explains why depressed individuals have difficulty concentrating or remembering things in their daily lives. This preoccupation of memory by depressive thoughts might also explain why more positive thoughts are often absent in depression; there simply is not enough space for them.”

The authors suggest that this greater dedication of memory resources to depressive thoughts and consequently, an impoverished ability to hold positive thoughts in memory, might be the key to understanding how depression develops and continues throughout an individual’s lifespan.

“Interventions such as mindfulness-based cognitive therapy are quite successful in empowering depressed people to recognize and better regulate the content of their thoughts,” said Dr. Rypma. “Our goal is to continue to study how such therapeutic approaches can alter the depressed brain and how these alterations might result in better memory and outcomes for persons with depression.”

Support for this study was provided by the Dianne Cash Fellowship award, the Friends of BrainHealth and the Linda and Joel Robuck Distinguished New  Scientist Award.

BrainHealth® is a registered service mark of The University of Texas at Dallas