Belief about nicotine content in cigarette may change brain activity and craving

Wednesday, September 14, 2016

The study, recently published in Frontiers in Psychiatry, found that smoking a nicotine cigarette but believing that it lacked nicotine failed to satisfy cravings related to nicotine addiction. Contrary to their expectations, researchers found that in order to satisfy nicotine cravings, smokers had to not only smoke a cigarette with nicotine but also believe that they were smoking nicotine.

"These results suggest that for drugs to have an effect on a person, he or she needs to believe that the drug is present," said Dr. Xiaosi Gu, assistant professor in the School of Behavioral and Brain Sciences and the study's lead author.

The scientists used functional magnetic resonance imaging (fMRI) to capture neural activity in the insula cortex, a region of the brain that plays a role in diverse functions such as bodily perception and self-awareness. The insula cortex is also associated with drug cravings and addiction, Gu said.

Twenty-four chronic, nicotine-addicted smokers participated in the double-blind study. Over four visits, participants were twice given a nicotine-containing cigarette and twice a placebo. With each type of cigarette, they were once accurately told what type they had and once told the opposite.

"We examined the impact of beliefs about cravings prior to and after smoking while also measuring neural activity," said Gu, who also serves as the head of the Computational Psychiatry Unit at the Center for BrainHealth.
 

Continue Reading >>
BrainHealth® is a registered service mark of The University of Texas at Dallas